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Kinetic-segregation model of T cell activation : ウィキペディア英語版 | Kinetic-segregation model of T cell activation
Kinetic-segregation model of T-cell activation is one of the TCR signaling models. It offers an explanation for how TCR binding to its ligand triggers T-cell activation, based on size-sensitivity for the molecules involved. Simon J. Davis and Anton van der Merwe, University of Oxford, proposed this model in 1996. Kinetic-segregation model was originally used to elucidate how binding of TCR to peptide-MHC-complex on APC is communicated across the T-cell membrane resulting in T-cell activation. However, its authors suggest it might be also applied to CD28 triggering by superagonistic antibodies (mitogenic antibodies). ==Applications of the proposed mechanism==
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